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Antigen delivery by α 2 ‐macroglobulin enhances the cytotoxic T lymphocyte response
Author(s) -
Bowers Edith V.,
Horvath Jeffrey J.,
Bond Jennifer E.,
Cianciolo George J.,
Pizzo Salvatore V.
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1008653
Subject(s) - ctl* , biology , antigen , cytotoxic t cell , elispot , cd8 , immunology , microbiology and biotechnology , t cell , immune system , in vitro , biochemistry
α‐ 2 M*‐mediated antigen delivery leads to cross‐presentation and improved cell‐mediated immunity, suggesting that α‐ 2 M* may have applications for vaccines based on weakly immunogenic subunits.