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The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
Author(s) -
Ehrchen Jan M.,
Sunderkötter Cord,
Foell Dirk,
Vogl Thomas,
Roth Johannes
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1008647
Subject(s) - s100a9 , s100a8 , biology , inflammation , innate immune system , immunology , calprotectin , pattern recognition receptor , immune system , cancer research , microbiology and biotechnology , medicine , pathology , disease , inflammatory bowel disease
S100A8 and S100A9 are novel members of the group of damage–associated molecular pattern molecules (DAMP) which are early amplifiers of innate immune responses to tissue damage or danger signals.