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Anti‐ Candida activity of α‐melanocyte‐stimulating hormone (α‐MSH) peptides
Author(s) -
Rauch Isabella,
Holzmeister Simone,
Kofler Barbara
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1008614
Subject(s) - candida albicans , melanocyte stimulating hormone , biology , tripeptide , neuropeptide , antimicrobial peptides , corpus albicans , biological activity , oligopeptide , amino acid , peptide , biochemistry , microbiology and biotechnology , hormone , endocrinology , receptor , in vitro
Previously, α‐MSH, a 13‐amino acid neuropeptide and the tripeptide α‐MSH have been shown to possess potent antimicrobial properties. We performed microplate based growth inhibition assays on C. albicans with α‐MSH, but could not observe any growth inhibiting effect. Repeating the originally published assay with different C. albicans strains, we detected a mild growth inhibiting effect of 100 μM α‐MSH, but again no effect of α‐MSH.