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Gfi‐1 is the transcriptional repressor of SOCS1 in acute myeloid leukemia cells
Author(s) -
Lee MingCheng,
Kuo YuanYeh,
Chou WenChien,
Hou HsinAn,
Hsiao Michael,
Tien HweiFang
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0912475
Subject(s) - suppressor of cytokine signaling 1 , gene knockdown , gene silencing , repressor , biology , microbiology and biotechnology , methylation , promoter , regulation of gene expression , small hairpin rna , transcription factor , cancer research , gene expression , gene , genetics , suppressor
SOCS1 inactivation may be caused by Gfi‐1 expression in AML cells; inhibition of H3K9 methyltransferase can rescue SOCS1 expression.