Inhibition of caspase‐8 activity promotes protective Th1‐ and Th2‐mediated immunity to  Leishmania major  infection | Zendy

PereiraManfro Wânia F. | Zendy; RibeiroGomes Flávia L. | Zendy; Filardy Alessandra Almeida | Zendy; Vellozo Natália S. | Zendy; Guillermo Landi V. C. | Zendy; Silva Elisabeth M. | Zendy; Siegel Richard M. | Zendy; DosReis George A. | Zendy; Lopes Marcela F. | Zendy

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Inhibition of caspase‐8 activity promotes protective Th1‐ and Th2‐mediated immunity to Leishmania major infection

Author(s) -

PereiraManfro Wânia F.,

RibeiroGomes Flávia L.,

Filardy Alessandra Almeida,

Vellozo Natália S.,

Guillermo Landi V. C.,

Silva Elisabeth M.,

Siegel Richard M.,

DosReis George A.,

Lopes Marcela F.

Publication year - 2014

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0912463

Subject(s) - biology , blockade , caspase 8 , immunology , leishmania major , apoptosis , immunity , cytokine , caspase , fas ligand , immune system , programmed cell death , leishmania , cancer research , microbiology and biotechnology , receptor , parasite hosting , biochemistry , world wide web , computer science

T cell expression of caspase‐8 inhibitor vFLIP provides a Th1 cytokine environment, along with a protective Th2 response that increases immunity to Leishmania major infection.

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