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Inhibition of caspase‐8 activity promotes protective Th1‐ and Th2‐mediated immunity to Leishmania major infection
Author(s) -
PereiraManfro Wânia F.,
RibeiroGomes Flávia L.,
Filardy Alessandra Almeida,
Vellozo Natália S.,
Guillermo Landi V. C.,
Silva Elisabeth M.,
Siegel Richard M.,
DosReis George A.,
Lopes Marcela F.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0912463
Subject(s) - biology , blockade , caspase 8 , immunology , leishmania major , apoptosis , immunity , cytokine , caspase , fas ligand , immune system , programmed cell death , leishmania , cancer research , microbiology and biotechnology , receptor , parasite hosting , biochemistry , world wide web , computer science
T cell expression of caspase‐8 inhibitor vFLIP provides a Th1 cytokine environment, along with a protective Th2 response that increases immunity to Leishmania major infection.