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Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments
Author(s) -
Marwick John A.,
Dorward David A.,
Lucas Christopher D.,
Jones Katie O.,
Sheldrake Tara A.,
Fox Sarah,
Ward Carol,
Murray Joanna,
Brittan Mairi,
Hirani Nik,
Duffin Rodger,
Dransfield Ian,
Haslett Christopher,
Rossi Adriano G.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0912462
Subject(s) - inflammation , dexamethasone , hypoxia (environmental) , immunology , apoptosis , proinflammatory cytokine , biology , respiratory burst , neutrophil extracellular traps , granulocyte , cytokine , oxygen , endocrinology , chemistry , biochemistry , organic chemistry
Glucocorticoids lack the capacity to further augment neutrophil survival, in severe hypoxia.