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Regulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se
Author(s) -
Su Yan,
Rossi Robert,
De Groot Anne S.,
Scott David W.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0912441
Subject(s) - immunogenicity , epitope , biology , in vivo , antigen , immune system , immunology , immune tolerance , cytokine , in vitro , antibody , t cell , context (archaeology) , immunoglobulin g , biochemistry , paleontology , microbiology and biotechnology
Tregitopes are capable of inducing tolerance, but lack immunogenicity in vivo, suggesting they are safe for future clinical applications.