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Thrombin‐induced CCN2 expression in human lung fibroblasts requires the c‐Src/JAK2/STAT3 pathway
Author(s) -
Bai KuaJen,
Chen BingChang,
Pai HuiChen,
Weng ChihMing,
Yu ChungChi,
Hsu MingJen,
Yu MingChih,
Ma HonPing,
Wu ChihHsiung,
Hong ChuangYe,
Kuo MinLiang,
Lin ChienHuang
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0911449
Subject(s) - thrombin , transfection , phosphorylation , biology , microbiology and biotechnology , proto oncogene tyrosine protein kinase src , small interfering rna , signal transduction , cancer research , cell culture , immunology , platelet , genetics
Thrombin might activate c‐Src to induce JAK2 activation, which causes STAT3 activation, inducing CCN2 expression in human lung fibroblasts.
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