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The HIV‐1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation
Author(s) -
Wallet Mark A.,
Reist Caroline M.,
Williams Julie C.,
Appelberg Sofia,
Guiulfo Giorgio L.,
Gardner Brent,
Sleasman John W.,
Goodenow Maureen M.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0911447
Subject(s) - nelfinavir , inflammation , biology , monocyte , macrophage , signal transduction , phosphorylation , proinflammatory cytokine , immunology , microbiology and biotechnology , cancer research , pharmacology , in vitro , biochemistry , viral load , virus , antiretroviral therapy
Nelfinavir has anti‐inflammatory effects directly upon human macrophages independent of antiviral activity.