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Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice
Author(s) -
Seeley Eric J.,
Sutherland Rachel E.,
Kim Sophia S.,
Wolters Paul J.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0910531
Subject(s) - degranulation , peritonitis , sepsis , immunology , biology , mast cell , biochemistry , genetics , receptor
Systemic mast cells degranulate during sepsis and mast cell‐derived products, including IL‐6, increase mortality during cecal ligation and puncture induced septic peritonitis in mice.