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IL‐23R and TCR signaling drives the generation of neonatal Vγ9Vδ2 T cells expressing high levels of cytotoxic mediators and producing IFN‐γ and IL‐17
Author(s) -
Moens Emmanuelle,
Brouwer Margreet,
Dimova Tanya,
Goldman Michel,
Willems Fabienne,
Vermijlen David
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0910501
Subject(s) - cytotoxic t cell , biology , granzyme , t cell receptor , immunology , t cell , immune system , perforin , population , interleukin 21 , microbiology and biotechnology , cd8 , medicine , biochemistry , in vitro , environmental health
IL‐23, highly produced by neonatal DC, promotes the generation of neonatal Vγ9Vδ2 T cells expressing a range of cytotoxic mediators and producing IFN‐γ and IL‐17
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