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Optimal TLR9 signal converts tolerogenic CD4 – 8 – DCs into immunogenic ones capable of stimulating antitumor immunity via activating CD4 + Th1/Th17 and NK cell responses
Author(s) -
Zhang Xueshu,
Munegowda Manjunatha Ankathatti,
Yuan Jinying,
Wei Yi,
Xiang Jim
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0909633
Subject(s) - biology , tlr9 , immunity , immunology , microbiology and biotechnology , immune system , genetics , gene , gene expression , dna methylation
Conversion of tolerogenic DCs into immunogenic ones by time‐limited CpG signaling allows for stimulation of antitumor immunity via activation of CD4 + Th1/Th17 and NK cell responses.