Technical Advance: Function and efficacy of an α 4 ‐integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis | Zendy

Murphy Carola T. | Zendy; Moloney Gerard | Zendy; MacSharry John | Zendy; Haynes Andrea | Zendy; Faivre Emilie | Zendy; Quinlan Aoife | Zendy; McLean Peter G. | Zendy; Lee Kevin | Zendy; OˈMahony Liam | Zendy; Shanahan Fergus | Zendy; Melgar Silvia | Zendy; Nally Kenneth | Zendy

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Technical Advance: Function and efficacy of an α 4 ‐integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis

Author(s) -

Murphy Carola T.,

Moloney Gerard,

MacSharry John,

Haynes Andrea,

Faivre Emilie,

Quinlan Aoife,

McLean Peter G.,

Lee Kevin,

OˈMahony Liam,

Shanahan Fergus,

Melgar Silvia,

Nally Kenneth

Publication year - 2010

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0909627

Subject(s) - bioluminescence imaging , leukocyte trafficking , integrin , colitis , in vivo , biology , antagonist , inflammation , ex vivo , immunology , pharmacology , pathology , cancer research , receptor , medicine , luciferase , cell culture , chemokine , transfection , biochemistry , genetics , microbiology and biotechnology

Method for in vivo bioluminescence imaging as a valuable strategy for pre‐clinical evaluation of leukocyte trafficking as shown here for small molecule α 4 ‐integrin antagonists as a promising therapeutic for IBD.

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