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Technical Advance: Function and efficacy of an α 4 ‐integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis
Author(s) -
Murphy Carola T.,
Moloney Gerard,
MacSharry John,
Haynes Andrea,
Faivre Emilie,
Quinlan Aoife,
McLean Peter G.,
Lee Kevin,
OˈMahony Liam,
Shanahan Fergus,
Melgar Silvia,
Nally Kenneth
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0909627
Subject(s) - bioluminescence imaging , leukocyte trafficking , integrin , colitis , in vivo , biology , antagonist , inflammation , ex vivo , immunology , pharmacology , pathology , cancer research , receptor , medicine , luciferase , cell culture , chemokine , transfection , biochemistry , genetics , microbiology and biotechnology
Method for in vivo bioluminescence imaging as a valuable strategy for pre‐clinical evaluation of leukocyte trafficking as shown here for small molecule α 4 ‐integrin antagonists as a promising therapeutic for IBD.