Premium
TNF‐α, IL‐6, and IL‐1 expression is inhibited by GAS6 in monocytes/macrophages
Author(s) -
Alciato Federica,
Sainaghi Pier Paolo,
Sola Daniele,
Castello Luigi,
Avanzi Gian Carlo
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0909610
Subject(s) - biology , cytokine , protein kinase b , gas6 , phosphorylation , pi3k/akt/mtor pathway , immune system , macrophage , u937 cell , microbiology and biotechnology , tumor necrosis factor alpha , secretion , signal transduction , monocyte , proinflammatory cytokine , inflammation , cancer research , immunology , endocrinology , in vitro , biochemistry , receptor tyrosine kinase
Gas6 is able to inhibit pro‐inflammatory cytokine secretion by macrophages acting on Mer receptor; the pathway involved is mediated by PI3K, Akt, GSK3β, and NFκB.