TNF‐α, IL‐6, and IL‐1 expression is inhibited by GAS6 in monocytes/macrophages | Zendy

Alciato Federica | Zendy; Sainaghi Pier Paolo | Zendy; Sola Daniele | Zendy; Castello Luigi | Zendy; Avanzi Gian Carlo | Zendy

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TNF‐α, IL‐6, and IL‐1 expression is inhibited by GAS6 in monocytes/macrophages

Author(s) -

Alciato Federica,

Sainaghi Pier Paolo,

Sola Daniele,

Castello Luigi,

Avanzi Gian Carlo

Publication year - 2010

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0909610

Subject(s) - biology , cytokine , protein kinase b , gas6 , phosphorylation , pi3k/akt/mtor pathway , immune system , macrophage , u937 cell , microbiology and biotechnology , tumor necrosis factor alpha , secretion , signal transduction , monocyte , proinflammatory cytokine , inflammation , cancer research , immunology , endocrinology , in vitro , biochemistry , receptor tyrosine kinase

Gas6 is able to inhibit pro‐inflammatory cytokine secretion by macrophages acting on Mer receptor; the pathway involved is mediated by PI3K, Akt, GSK3β, and NFκB.

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