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DNA demethylating agent 5‐azacytidine inhibits myeloid‐derived suppressor cells induced by tumor growth and cyclophosphamide treatment
Author(s) -
Mikyšková Romana,
Indrová Marie,
Vlková Veronika,
Bieblová Jana,
Šímová Jana,
Paračková Zuzana,
PajtaszPiasecka Elzbieta,
Rossowska Joanna,
Reiniš Milan
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0813435
Subject(s) - cancer research , demethylating agent , spleen , cd86 , tumor microenvironment , cd11c , biology , myeloid derived suppressor cell , immunosuppression , immunology , suppressor , cancer , immune system , t cell , dna methylation , gene expression , gene , phenotype , tumor cells , biochemistry , genetics
Direct effects of DNA demethylating agent 5‐azacytidine on immunosuppressive myeloid cell subsets in cancer, suggest that co‐administration of 5AC could improve therapeutic efficacy of existing cancer therapy.