z-logo
Premium
HMG‐CoA reductase inhibitors activate caspase‐1 in human monocytes depending on ATP release and P2X7 activation
Author(s) -
Liao YiHsiang,
Lin YiChieh,
Tsao ShihTing,
Lin YingCing,
Yang AiJen,
Huang ChenTsung,
Huang KuoChin,
Lin Wan Wan
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0812409
Subject(s) - inflammasome , statin , caspase 1 , fluvastatin , cathepsin , biology , secretion , hmg coa reductase , microbiology and biotechnology , pharmacology , reductase , inflammation , biochemistry , simvastatin , immunology , enzyme
Statin‐induced caspase‐1 activation and IL‐1β release are due to unmask the anti‐inflammatory action of isoprenoids by activating P2X7.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here