Premium
HMG‐CoA reductase inhibitors activate caspase‐1 in human monocytes depending on ATP release and P2X7 activation
Author(s) -
Liao YiHsiang,
Lin YiChieh,
Tsao ShihTing,
Lin YingCing,
Yang AiJen,
Huang ChenTsung,
Huang KuoChin,
Lin Wan Wan
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0812409
Subject(s) - inflammasome , statin , caspase 1 , fluvastatin , cathepsin , biology , secretion , hmg coa reductase , microbiology and biotechnology , pharmacology , reductase , inflammation , biochemistry , simvastatin , immunology , enzyme
Statin‐induced caspase‐1 activation and IL‐1β release are due to unmask the anti‐inflammatory action of isoprenoids by activating P2X7.