Premium
IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2‐mediated tolerance
Author(s) -
Xiong Yanbao,
Pennini Meghan,
Vogel Stefanie N.,
Medvedev Andrei E.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0812401
Subject(s) - biology , tlr4 , tlr2 , proinflammatory cytokine , kinase , p38 mitogen activated protein kinases , microbiology and biotechnology , signal transduction , mapk/erk pathway , immunology , inflammation
IRAK4 kinase‐inactive macrophages exhibit attenuated TLR2‐ and TLR4‐mediated signaling and normal induction of endotoxin tolerance, while TLR2‐mediated homotolerance, and TLR2‐mediated TLR4 heterotolerance, are deficient.