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Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: insight into the molecular mechanisms
Author(s) -
Demoulin Stéphanie,
Herfs Michael,
Delvenne Philippe,
Hubert Pascale
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0812397
Subject(s) - biology , immune system , tumor microenvironment , reprogramming , immunology , immunosuppression , acquired immune system , immunity , cancer , secretion , cancer research , immune tolerance , innate immune system , population , cancer immunotherapy , immunotherapy , cell , medicine , biochemistry , genetics , environmental health
Review of neoplastic lesions associated with infiltration of immunosuppressive pDC and the molecular pathways developed by tumors, to prevent antitumoral pDC responses.