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Krüppel‐like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen
Author(s) -
Shik Park Chun,
Lee PingHsien,
Yamada Takeshi,
Burns Audrea,
Shen Ye,
Puppi Monica,
Lacorazza H. Daniel
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0811413
Subject(s) - biology , klf4 , spleen , haematopoiesis , cd11c , interleukin 12 , interleukin 21 , progenitor cell , immunology , stem cell , microbiology and biotechnology , cancer research , t cell , cytotoxic t cell , immune system , transcription factor , sox2 , gene , biochemistry , in vitro , phenotype
Loss of KLF4 leads to increased apoptosis of NK cells and reduced differentiation of dendritic cells in the spleen at steady state.