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IFN‐α produced by human plasmacytoid dendritic cells enhances T cell‐dependent naïve B cell differentiation
Author(s) -
Gujer Cornelia,
Sandgren Kerrie J.,
Douagi Iyadh,
Adams William C.,
Sundling Christopher,
SmedSörensen Anna,
Seder Robert A.,
Hedestam Gunilla B. Karlsson,
Loré Karin
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0810460
Subject(s) - cd40 , cd86 , cd80 , biology , naive b cell , b cell , antigen presenting cell , il 2 receptor , microbiology and biotechnology , b 1 cell , cd19 , interleukin 21 , cytotoxic t cell , mhc class ii , t cell , immune system , immunology , antibody , in vitro , biochemistry
Plasmacytoid dendritic cells via their production of IFN‐α render B cells more receptive to T cell contact which facilitates B cell proliferation and differentiation.