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Statins inhibit T‐acute lymphoblastic leukemia cell adhesion and migration through Rap1b
Author(s) -
Infante Elvira,
Heasman Sarah J.,
Ridley Anne J.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0810441
Subject(s) - rhoa , rap1 , prenylation , microbiology and biotechnology , biology , farnesyltransferase inhibitor , cell adhesion , rac1 , cdc42 , gtpase , cell migration , ras superfamily , signal transduction , cancer research , farnesyltransferase , cell , biochemistry , gtp' , enzyme
Statins inhibit T‐ALL cell chemotaxis, transendothelial migration, and adhesion to ICAM‐1, which correlates with reduced function of the GTPase Rap1b but not Rap1a.