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Pivotal Advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine‐polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms
Author(s) -
Kaczorowski David J.,
Afrazi Amin,
Scott Melanie J.,
Kwak Joon H.,
Gill Roop,
Edmonds Rebecca D.,
Liu Yujian,
Fan Jie,
Billiar Timothy R.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0809588
Subject(s) - trif , tlr4 , lipopolysaccharide , biology , complement factor b , tlr3 , macrophage , tumor necrosis factor alpha , microbiology and biotechnology , receptor , inflammation , stimulation , complement system , immunology , toll like receptor , immune system , innate immune system , biochemistry , endocrinology , in vitro
Stimulation of TLR4 by LPS results in factor B synthesis by macrophages, while factor B production in response to poly I:C is independent of TRL3 and TRIF.