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The catalytic PI3K isoforms p110γ and p110δ contribute to B cell development and maintenance, transformation, and proliferation
Author(s) -
BeerHammer Sandra,
Zebedin Eva,
Holleben Max,
Alferink Judith,
Reis Bernhard,
Dresing Philipp,
Degrandi Daniel,
Scheu Stefanie,
Hirsch Emilio,
Sexl Veronika,
Pfeffer Klaus,
Nürnberg Bernd,
Piekorz Roland P.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0809585
Subject(s) - biology , p110α , b cell , cd19 , gene isoform , cell growth , microbiology and biotechnology , pi3k/akt/mtor pathway , immunology , signal transduction , flow cytometry , genetics , gene , antibody
PI3K isoforms p110γ and p110δ are required for early B cell development, peripheral maintenance, transformation by the Abelson oncogene, and LPS‐induced proliferation.