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Decreased ERK and JNK signaling contribute to gene overexpression in “senescent” CD4+CD28– T cells through epigenetic mechanisms
Author(s) -
Chen Yingxuan,
Gorelik Gabriela J.,
Strickland Faith M.,
Richardson Bruce C.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0809562
Subject(s) - biology , dna methylation , mapk/erk pathway , cd28 , epigenetics , signal transduction , microbiology and biotechnology , dnmt1 , chromatin , cancer research , methylation , dna demethylation , immunology , gene expression , t cell , gene , immune system , genetics
Decreased ERK and JNK signaling in CD4+CD28− T cells decreases DNA methyltransferase levels causes demethylation and overexpression of genes normally suppressed by chromatin structure.