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Mycobacterium tuberculosis induces IL‐17A responses through TLR4 and dectin‐1 and is critically dependent on endogenous IL‐1
Author(s) -
Veerdonk Frank L.,
Teirlinck Anne C.,
Kleinnijenhuis Johanneke,
Kullberg Bart Jan,
Crevel Reinout,
Meer Jos W. M.,
Joosten Leo A. B.,
Netea Mihai G.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0809550
Subject(s) - tlr4 , biology , tlr2 , proteases , endogeny , mycobacterium tuberculosis , signal transduction , mapk/erk pathway , interleukin 17 , microbiology and biotechnology , receptor , intracellular , immunology , cytokine , tuberculosis , enzyme , biochemistry , medicine , pathology
IL‐17A production induced by Mycobacterium tuberculosis through TLR4 and dectin‐1 is dependent on the steps necessary for the induction of endogenous IL‐1β.