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PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA‐PI3K/Akt‐dependent and NF‐κB‐independent manner
Author(s) -
Sousa Lirlândia P.,
Lopes Fernando,
Silva Douglas M.,
Tavares Luciana P.,
Vieira Angélica T.,
Rezende Bárbara M.,
Carmo Aline F.,
Russo Remo C.,
Garcia Cristiana C.,
Bonjardim Cláudio A.,
Alessandri Ana L.,
Rossi Adriano G.,
Pinho Vanessa,
Teixeira Mauro M.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0809540
Subject(s) - rolipram , inflammation , protein kinase b , apoptosis , pi3k/akt/mtor pathway , biology , pharmacology , endocrinology , medicine , immunology , phosphodiesterase , biochemistry , enzyme
PDE4 inhibition is effective at resolving neutrophilic inflammation after LPS‐challenge by promoting caspase‐3‐dependent apoptosis of inflammatory cells in the pleural cavity.