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The disconnect between animal models of sepsis and human sepsis
Author(s) -
Rittirsch Daniel,
Hoesel L. Marco,
Ward Peter A.
Publication year - 2007
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0806542
Subject(s) - sepsis , biology , peritonitis , animal model , pathophysiology , bacteremia , blockade , ligation , intensive care medicine , immunology , medicine , antibiotics , microbiology and biotechnology , receptor , endocrinology , genetics , biochemistry
Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of bacteria or bacterial products (such as LPS). Many of these models mimic the pathophysiology of human sepsis. However, identification of mediators in animals, the blockade of which has been protective, has not translated into clinical efficacy in septic humans. We describe the shortcomings of the animal models and reasons why effective therapy for human sepsis cannot be derived readily from promising findings in animal sepsis.