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Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration
Author(s) -
Maina Virginia,
Marrella Veronica,
Mantero Stefano,
Cassani Barbara,
Fontana Elena,
Anselmo Achille,
Del Prete Annalisa,
Sozzani Silvano,
Vezzoni Paolo,
Poliani Pietro Luigi,
Villa Anna
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0713365
Subject(s) - rag2 , biology , immunology , dendritic cell , severe combined immunodeficiency , primary immunodeficiency , phenotype , haematopoiesis , autoimmunity , t cell , immunodeficiency , in vivo , microbiology and biotechnology , immune system , gene , stem cell , genetics , recombination
In Omenn syndrome, altered dendritic cell distribution and impaired migration represent an additional level of immune dysregulation, contributing to the pathogenesis of autoimmunity.

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