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A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser 727 phosphorylation in mouse macrophages
Author(s) -
Alamuru Neeraja P.,
Behera Soma,
Butchar Jonathan P.,
Tridandapani Susheela,
Kaimal Suraj Sasidhara,
Babu P. Prakash,
Hasnain Seyed E.,
Ehtesham Nasreen Z.,
Parsa Kishore V. L.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0713360
Subject(s) - phosphorylation , stat1 , gene knockdown , biology , p38 mitogen activated protein kinases , gene silencing , innate immune system , immune system , microbiology and biotechnology , cancer research , immunology , mapk/erk pathway , biochemistry , gene
PHLPP1 inhibited LPS/IFNγ stimulated inducible nitric oxide synthase expression as a novel regulator of macrophage responses.