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Nucleotide receptor P2RX 7 stimulation enhances LPS‐induced interferon‐β production in murine macrophages
Author(s) -
Gavala M. L.,
Liu Y.P.,
Lenertz L. Y.,
Zeng L.,
Blanchette J. B.,
Guadarrama A. G.,
Denlinger L. C.,
Bertics P. J.,
Smith J. A.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0712351
Subject(s) - biology , purinergic receptor , transcription factor , stimulation , microbiology and biotechnology , proinflammatory cytokine , receptor , mapk/erk pathway , interferon regulatory factors , signal transduction , extracellular , immunology , inflammation , gene , biochemistry , endocrinology
LPS‐induced IFN‐β is enhanced in macrophages upon activation of P2RX7, potentially related to an increase in active IRF‐3.