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The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development
Author(s) -
Savino Maria Teresa,
Ulivieri Cristina,
Emmi Giacomo,
Prisco Domenico,
De Falco Giulia,
Ortensi Barbara,
Beccastrini Enrico,
Emmi Lorenzo,
Pelicci Giuliana,
DˈElios Mario M.,
Baldari Cosima T.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0712331
Subject(s) - biology , autoimmunity , proinflammatory cytokine , immunology , lupus nephritis , t cell , microbiology and biotechnology , regulator , effector , signal transducing adaptor protein , signal transduction , cancer research , inflammation , immune system , medicine , disease , biochemistry , gene
Rai prevents lupus nephritis by impairing the development and expansion of both proinflammatory Th17 and Th1 cells.