Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression | Zendy

Rossi Lucas E. | Zendy; Avila Damián E. | Zendy; Spallanzani Raúl G. | Zendy; Ziblat Andrea | Zendy; Fuertes Mercedes B. | Zendy; Lapyckyj Lara | Zendy; Croci Diego O. | Zendy; Rabinovich Gabriel A. | Zendy; Domaica Carolina I. | Zendy; Zwirner Norberto W. | Zendy

Premium

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression

Author(s) -

Rossi Lucas E.,

Avila Damián E.,

Spallanzani Raúl G.,

Ziblat Andrea,

Fuertes Mercedes B.,

Lapyckyj Lara,

Croci Diego O.,

Rabinovich Gabriel A.,

Domaica Carolina I.,

Zwirner Norberto W.

Publication year - 2012

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0711339

Subject(s) - nkg2d , biology , interleukin 21 , histone deacetylase , immune system , il 2 receptor , cytotoxicity , interleukin 12 , histone deacetylase inhibitor , janus kinase 3 , cancer research , cytokine , microbiology and biotechnology , lymphokine activated killer cell , immunology , t cell , cytotoxic t cell , in vitro , histone , biochemistry , gene

Histone deacetylase inhibitors (HDACi) severely impair NK cell‐mediated functions, which has translational consequences as HDACi could weaken immune surveillance and promote relapse in treated patients.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research