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Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression
Author(s) -
Rossi Lucas E.,
Avila Damián E.,
Spallanzani Raúl G.,
Ziblat Andrea,
Fuertes Mercedes B.,
Lapyckyj Lara,
Croci Diego O.,
Rabinovich Gabriel A.,
Domaica Carolina I.,
Zwirner Norberto W.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0711339
Subject(s) - nkg2d , biology , interleukin 21 , histone deacetylase , immune system , il 2 receptor , cytotoxicity , interleukin 12 , histone deacetylase inhibitor , janus kinase 3 , cancer research , cytokine , microbiology and biotechnology , lymphokine activated killer cell , immunology , t cell , cytotoxic t cell , in vitro , histone , biochemistry , gene
Histone deacetylase inhibitors (HDACi) severely impair NK cell‐mediated functions, which has translational consequences as HDACi could weaken immune surveillance and promote relapse in treated patients.