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IL‐7‐dependent STAT‐5 activation and CD8 + T cell proliferation are impaired in HIV infection
Author(s) -
Vranjkovic Agatha,
Crawley Angela M.,
Patey Andrea,
Angel Jonathan B.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0710430
Subject(s) - interleukin 7 receptor , biology , cd8 , stat5 , cytotoxic t cell , flow cytometry , immunology , t cell , immune system , il 2 receptor , signal transduction , microbiology and biotechnology , in vitro , genetics
IL‐7/IL‐7R dysfunction in HIV infection may contribute to IL‐7‐specific signaling defects and may negatively impact the maintenance of CD8 + T cell responsiveness.
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