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Modulated selection of IGHV gene somatic hypermutation during systemic maturation of human plasma cells
Author(s) -
JiménezGómez Gema,
GómezPerales Jesús L.,
RamosAmaya Ana,
GonzálezGarcía Inés,
CamposCaro Antonio,
Brieva José A.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0709514
Subject(s) - somatic hypermutation , biology , ighv@ , somatic cell , gene , selection (genetic algorithm) , genetics , microbiology and biotechnology , positive selection , immunology , antibody , b cell , leukemia , chronic lymphocytic leukemia , artificial intelligence , computer science
This study focuses on the regulation of Ig gene variability and the rules and limits of the adaptability of IGHV genes from human plasma cells.