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The adaptor protein p66shc is a positive regulator in the angiogenic response induced by hypoxic T cells
Author(s) -
Naldini Antonella,
Morena Emilia,
Pucci Annalisa,
Pellegrini Michela,
Baldari Cosima T.,
Pelicci Pier Giuseppe,
Presta Marco,
Ribatti Domenico,
Carraro Fabio
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0709460
Subject(s) - regulator , angiogenesis , biology , microbiology and biotechnology , jurkat cells , signal transducing adaptor protein , splenocyte , immune system , neovascularization , hypoxia (environmental) , cancer research , immunology , t cell , signal transduction , chemistry , biochemistry , gene , organic chemistry , oxygen
The present study demonstrates that hypoxia activates a novel T cell‐mediated mechanism of neovascularization triggered by VEGF in which p66Shc acts as the master regulator.