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TLR4‐mediated Cox‐2 expression increases intestinal ischemia/reperfusion‐induced damage
Author(s) -
Moses Tiffany,
Wagner Lynn,
Fleming Sherry D.
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0708396
Subject(s) - tlr4 , inflammation , eicosanoid , biology , reperfusion injury , receptor , stimulation , immune system , prostaglandin e2 , immunology , ischemia , cancer research , endocrinology , medicine , biochemistry , arachidonic acid , enzyme
TLR4 stimulates Cox‐2‐mediated PGE2 production which is necessary but not sufficient for intestinal ischemia/reperfusion‐induced damage and inflammation.