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Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection
Author(s) -
Lin Yinling,
Roberts Tonya J.,
Spence Philip M.,
Brutkiewicz Randy R.
Publication year - 2005
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0704399
Subject(s) - biology , cd1d , virus , microbiology and biotechnology , virology , dendritic cell , immunology , macrophage , expression (computer science) , immune system , in vitro , t cell , natural killer t cell , genetics , computer science , programming language
Mice were infected with lymphocytic choriomeningitis virus (LCMV) to determine if changes in CD1d expression occurred during an acute virus infection. It is interesting that a decrease in CD1d expression on splenic dendritic cells (DC) and macrophages (MΦ) was observed for at least 3 months post‐LCMV infection, and vaccinia virus and vesicular stomatitis virus induced similar changes in CD1d upon infection with those viruses. The reduction of CD1d cell‐surface expression on DC and MΦ was independent of interferon‐γ and interleukin‐12 expression but partially recovered in transporter associated with antigen processing‐1‐deficient mice, suggesting that CD8 + T cells may play a role. Thus, one consequence of the induction of a cellular immune response is a change in CD1d expression, which may constitute a key element in regulating antiviral immunity.