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β‐Catenin mediates tumor‐induced immunosuppression by inhibiting cross‐priming of CD8 + T cells
Author(s) -
Liang Xinjun,
Fu Chunmei,
Cui Weiguo,
OberBlöbaum Julia L.,
Zahner Sonja P.,
Shrikant Protul A.,
Clausen Björn E.,
Flavell Richard A.,
Mellman Ira,
Jiang Aimin
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0613330
Subject(s) - priming (agriculture) , biology , cd8 , cytotoxic t cell , antigen , immunology , t cell , immunity , immune system , cross presentation , cancer research , mhc class i , in vitro , biochemistry , botany , germination
Tumors activate β‐catenin in DCs to suppress CD8 immunity by inhibiting cross‐priming; β‐catenin‐suppressed CD8 immunity could be rescued by enhancing cross‐priming.