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Rosiglitazone‐induced CD36 up‐regulation resolves inflammation by PPARγ and 5‐LO‐dependent pathways
Author(s) -
Ballesteros Iván,
Cuartero María I.,
Pradillo Jesús M.,
Parra Juan,
PérezRuiz Alberto,
Corbí Ángel,
Ricote Mercedes,
Hamilton John A.,
Sobrado Mónica,
Vivancos José,
Nombela Florentino,
Lizasoain Ignacio,
Moro María A.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0613326
Subject(s) - biology , rosiglitazone , cd36 , inflammation , peroxisome proliferator activated receptor , microbiology and biotechnology , signal transduction , receptor , medicine , endocrinology , immunology , genetics
PPARγ activation with RSG induces 5‐LO‐dependent CD36 expression in resident microglia that participates in resolution of inflammation by phagocytosis, in an experimental model of stroke.