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Aggressive disease defined by cytogenetics is associated with cytokine dysregulation in CLL/SLL patients
Author(s) -
Karmali Reem,
Paganessi Laura A.,
Frank Robin R.,
Jagan Sucheta,
Larson Melissa L.,
Venugopal Parameswaran,
Gregory Stephanie A.,
Christopherson Kent W.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0612301
Subject(s) - cytokine , biology , context (archaeology) , immunology , cytogenetics , disease , oncology , medicine , asymptomatic , gene , genetics , paleontology , chromosome
Specific cytokine signatures correlate with genetic aberrations in CLL/SLL, reflecting a pattern of Th1/Th2/Treg dysregulation that may predict aggressive disease, and a need for therapy.