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P2X7 receptor‐mediated Nlrp3‐inflammasome activation is a genetic determinant of macrophage‐dependent crescentic glomerulonephritis
Author(s) -
Deplano Simona,
Cook H. Terence,
Russell Ryan,
Franchi Luigi,
Schneiter Sabine,
Bhangal Gurjeet,
Unwin Robert J.,
Pusey Charles D.,
Tam Frederick W. K.,
Behmoaras Jacques
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0612284
Subject(s) - inflammasome , biology , pyrin domain , receptor , caspase 1 , macrophage , microbiology and biotechnology , immunology , genetics , in vitro
A novel mechanism in genetically determined P2RX7 levels in macrophages regulates Nlrp3‐inflammasome activation and susceptibility to crescentic glomerulonephritis.