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Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation
Author(s) -
Ries Moritz,
Schuster Philipp,
Thomann Sabrina,
Donhauser Norbert,
Vollmer Jörg,
Schmidt Barbara
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0612278
Subject(s) - biology , tlr9 , transfection , microbiology and biotechnology , cpg oligodeoxynucleotide , flow cytometry , cpg site , immune system , mitochondrial dna , internalization , dna fragmentation , cell , programmed cell death , apoptosis , cell culture , gene , immunology , genetics , dna methylation , gene expression
Fragmented mitochondrial DNA induces plasmacytoid dendritic cell maturation, migration, and IFN‐α production.