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Secreted virulence factors and immune evasion in visceral leishmaniasis
Author(s) -
Lambertz Ulrike,
Silverman Judith Maxwell,
Nandan Devki,
McMaster W. Robert,
Clos Joachim,
Foster Leonard J.,
Reiner Neil E.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0611326
Subject(s) - biology , leishmania , secretion , effector , virulence , immune system , macrophage , microbiology and biotechnology , microvesicles , virulence factor , pi3k/akt/mtor pathway , exosome , signal transduction , immunology , microrna , gene , genetics , parasite hosting , in vitro , biochemistry , world wide web , computer science
Review of leishmania secreted virulence factors and their immune‐modulatory functions, as well as exosome release as a major mechanism for effector secretion and delivery.