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Natural killer cell‐produced IFN‐γ and TNF‐α induce target cell cytolysis through up‐regulation of ICAM‐1
Author(s) -
Wang Ruipeng,
Jaw Jessica J.,
Stutzman Nicole C.,
Zou Zhongcheng,
Sun Peter D.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0611308
Subject(s) - cytolysis , biology , nk 92 , interleukin 21 , tumor necrosis factor alpha , janus kinase 3 , cytotoxic t cell , interleukin 12 , lymphokine activated killer cell , cytotoxicity , microbiology and biotechnology , natural killer cell , proinflammatory cytokine , interferon , immunology , t cell , immune system , inflammation , in vitro , biochemistry
Both IFN‐γ and TNF‐α are integral parts of NK effector machinery and they synergistically enhance the cytolytic function of NK cells.