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Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation
Author(s) -
Meunier Sylvain,
Rapetti Laëtitia,
Beziaud Laurent,
Pontoux Christiane,
Legrand Agnès,
Tanchot Corinne
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0611292
Subject(s) - cd40 , cd8 , biology , cytotoxic t cell , microbiology and biotechnology , immunology , t cell , cellular differentiation , antigen presenting cell , immune system , in vitro , biochemistry , gene
CD40 on APCs is important for CD8 expansion/effector function in primary response, whereas CD40 on CD8 T cells is involved in memory differentiation.
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