Premium
HIV inhibits early signal transduction events triggered by CD16 cross‐linking on NK cells, which are important for antibody‐dependent cellular cytotoxicity
Author(s) -
Lichtfuss Gregor F.,
Meehan Aislin C.,
Cheng WanJung,
Cameron Paul U.,
Lewin Sharon R.,
Crowe Suzanne M.,
Jaworowski Anthony
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0610371
Subject(s) - cd16 , biology , antibody dependent cell mediated cytotoxicity , cytotoxic t cell , flow cytometry , immunology , immunophenotyping , interleukin 21 , immunological synapse , microbiology and biotechnology , t cell , cd8 , antibody , cd3 , antigen , immune system , in vitro , t cell receptor , biochemistry , monoclonal antibody
Defective NK cell ADCC in whole blood from HIV‐infected patients due to impaired early signaling in response to CD16 surface receptor cross‐linking.