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Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen‐presenting potential of plasmacytoid DCs
Author(s) -
Kool Mirjam,
GeurtsVanKessel Corine,
Muskens Femke,
Madeira Fillipe Branco,
Nimwegen Menno,
Kuipers Harmjan,
Thielemans Kris,
Hoogsteden Henk C.,
Hammad Hamida,
Lambrecht Bart N.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0610342
Subject(s) - antigen processing , biology , antigen , cross presentation , microbiology and biotechnology , antigen presentation , endosome , epitope , t cell receptor , ctl* , endogeny , immune system , immunology , cd8 , t cell , mhc class i , intracellular , biochemistry
Timing of TLR ligation and facilitated antigen uptake dictate the potential of pDCs to present endogenous or exogenous Ag by influencing endosomal traffic and antigen processing machinery.