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Nitric oxide controls an inflammatory‐like Ly6C hi PDCA1 + DC subset that regulates Th1 immune responses
Author(s) -
Giordano Daniela,
Li Chang,
Suthar Mehul S.,
Draves Kevin E.,
Ma Daphne Y.,
Gale Michael,
Clark Edward A.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0610329
Subject(s) - immune system , biology , priming (agriculture) , immunology , in vivo , inflammation , nitric oxide , autocrine signalling , immunotherapy , receptor , endocrinology , biochemistry , botany , germination , microbiology and biotechnology
NO produced by DCs suppresses a Ly6ChiPDCA1 + DC subpopulation resembling inflammatory DCs, highly responsive to TLR stimulation and capable of initiating strong Th1 immune responses.