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Cholesterol 25‐hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
Author(s) -
Park Kiwon,
Scott Alan L.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0610318
Subject(s) - biology , microbiology and biotechnology , oxysterol , trif , signal transduction , stat1 , innate immune system , transcription factor , tlr4 , interferon type i , immune system , interferon , dendritic cell , toll like receptor , immunology , biochemistry , gene , cholesterol
TLR‐mediated induction of cholesterol 25‐hydoxylase transcription in dendritic cells and macrophages is dependent on IFN‐α/IFN‐β and signaling through INF‐αR and STAT1.