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Pivotal Advance: Phospholipids determine net membrane surface charge resulting in differential localization of active Rac1 and Rac2
Author(s) -
Magalhaes Marco A. O.,
Glogauer Michael
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0609390
Subject(s) - microbiology and biotechnology , biology , phagosome , chemotaxis , phagocytosis , pseudopodia , membrane , rac1 , cell membrane , membrane lipids , cytoplasm , biophysics , signal transduction , biochemistry , actin , receptor
Neutrophils regulate membrane lipid composition and membrane surface charge to localize signaling pathways through the recruitment of differentially charged proteins.